Vagifem (Estradiol)

Brand Name: Vagifem, Estrace, Femtrace, Gynodiol
Generic Name: estradiol vaginal

You can buy Vagifem online and without prescription.

Uses and Indications

Estradiol is a form of estrogen, a female sex hormone the regulates many processes in the body.

Vagifem is used to treat certain symptoms of menopause such as dryness, burning, and itching of the vaginal area. Estradiol vaginal also reduces urgency or irritation of urination.

Safe usage and general guidance

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor.

Squeeze the sides of the ring together and insert it into the vagina as far as possible. You should not be able to feel the ring once it is in place. If you can feel it, use a finger to push it in farther. It is not possible for the ring to go too far in or become lost. Leave the ring in place for 90 days. If the ring ever falls out, rinse it with warm water and reinsert it. If it slides down into the lower part of the vagina, use a finger to push it in farther. After 90 days, remove the ring. Your doctor may want you to replace it with a new ring.

The ring does not need to be removed during sexual intercourse. Neither partner should be able to feel the ring when it is in place. If the ring is bothersome, you may remove it, rinse it with warm water, and reinsert it after intercourse.

To remove the ring, loop a finger through the ring and gently pull it from the vagina.

Precautions and risks

Do not use this medication if you have any of the following conditions:

  • a history of stroke or blood clot,
  • circulation problems,
  • a hormone-related cancer such as breast or uterine cancer,
  • or abnormal vaginal bleeding.

This medication can cause birth defects in an unborn baby. Do not use if you are pregnant. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment.

Vagifem increases your risk of developing endometrial hyperplasia, a cancer of the uterus. Taking progestins while using estradiol may lower this risk.

Long-term estradiol treatment may increase your risk of breast cancer, heart attack, or stroke. Talk with your doctor about your individual risks before using estradiol long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.


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